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The effectiveness of clozaril in treatment-resistant schizophrenia was demonstrated in a 6-week, randomized, double-blind, active-controlled study comparing clozaril and chlorpromazine in patients who had failed other antipsychotics.

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although clozaril clozapine therapy may be resumed if no symptoms of infection develop, and when the wbc count rises above 3500 mm 3 and the anc rises above 2000 mm 3 , prescribers are strongly advised to consider whether the benefit of continuing clozaril clozapine treatment outweighs the increased risk of agranulocytosis.
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